Simulating Patient-Specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques
Simulating Patient-specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques – The vast majority of heart attacks occur when there is a sudden rupture of plaques, so-called vulnerable plaques, forming clots that can cause blockages in coronary arteries. The objective of the researchers’ work was to develop a computational tool-set to support the design and analysis of a catheter-based local nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. The goal is to rationally design drug-encapsulated nanoparticles in conjunction with patient-specific attributes and deliver drug locally to the diseased arteries, thereby personalizing and optimizing therapeutic intervention. To that end, a three-dimensional mathematical model of coupled transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis using the Texas Advanced Computing Center’s (TACC) HPC resources. The visualization component of this project, a 14 minute animation, seeks to explain the motivation of the research, the physical mechanism of the proposed solution concept, the mathematical models used, the computational methodology applied for simulation, and the scientific visualization of the results. Researchers Shaolie Hossain, PhD Institute for Computational Engineering and Sciences (ICES) The University of Texas at Austin Thomas JR Hughes, PhD Institute for Computational Engineering and Sciences (ICES) The University of Texas at Austin Visualization and video production Ben …
The soaring cost of military drugs
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High-priced specialty drugs, in particular, will continue to drive military drug spending, predicted Jim Wilson, a University of Texas College of Pharmacy professor and former head of the Army's pharmacy programs. …. While medical experts acknowledge …
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A look at top Yuma news stories for 2012
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Aric Liberman flew the new supersonic stealth fighter jet to the air station directly from Lockheed Martin's production plant in Fort Worth, Texas. …. The tunnel connected in San Luis, Ariz., to a building on Archibald Street that had been under …
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Meth lab suspect back in prison after getting kicked out of drug rehab program
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Jacob Berino, 19, of Texas Hill Road has denied a single charge of conspiracy to manufacture methamphetamine and was released on conditions, including he participate in and complete a drug treatment program, the U.S. Attorney's office said in court …
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Eureka Times Standard year in a review
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Jan 14 — ACRC shutters doors — The Arcata Community Recycling Center Board of Directors announced that the center's Samoa Processing Facility and 10th Street collection site in Arcata will no longer operate after today. Jan. … March 2 — Mikal …
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